Mutation Uncertainty	Opinions vary widely about what exactly constitutes a mutation and how they are produced varies widely. How does one know that a change is not just an expression of an already present but hidden genetic characteristic? Some even claim that the Cytoplash contains genetic coding capability and not the nucleus.
Mutation Frequency	Very rare naturally (due to DNS repair mechanism). Estimates vary from 1 in 10,000 to 1 in 1,000,000 or 1 in a million animals or once in a million lifetimes
How Goes Evolution	Simpson - probability of 5 mutations in the same nucleus = 10-22. "With an average breeding population of 100 million individuals and an average length of generation of one day, again extremely favorable postulates, such an event would be expected only once in 274 billion years, or about a hundred times the probable age of the earth. ... unless there is an unknown factor tremendously increasing the chance of simultaneous mutations, such as process has played no part whatever in evolutions."
Mutations Harmful	There is consensus among Evolutionists that mutations are harmful.
Fried	"We have to face one particular fact, one so peculiar that in the opinion of some people it makes nonsense of the whole theory of evolution. Although the Biological theory calls for incorporation of beneficial variants in the living populations, a vast majority of the mutants observed in any organism are detrimental to welfare. Some  are lethal, causing incurable diseases or deaths. Others are sub-lethal killing off or incapacitating most of the carriers but allowing some to escape. Still others are sub-vital, damaging health, resistance or vigor in a variety of ways."
Martin	"The mass of evidence show that all, or almost all, known mutations are unmistakably pathological and the few remaining ones are highly suspect..."
Mayr	"... It is a considerable strain on one's credulity to assume that finely balanced systems such as certain sense organs (the eye of vertebrates, or the bird's feather) could be improved upon by random mutations."
Nilsson	"... Therefore mutations are never found in nature (e.g. not a single one of the several hundreds of Drosophila Mutations), and therefore they are able to appear only in the favorable environment of the experimental field or laboratory..."
Dobzhansky	"A majority of mutations, both those arising in the laboratories and those stored in natural populations produce deteriorations of the viability, hereditary disease and monstrosities. Such changes it would seem, can hardly serve as evolutionary building blocks."
Increased Mutation Rate	The poor Fruit Fly (Drosophila) has been radiated, heated, gassed and tortured in all imaginable ways for nearly a hundred years - increased mutation rates of 15,000% - not a single beneficial change observed. But thousands of bizarre changes have been created and most often the result has been dead Fruit Flies.
Natural Selection	The thesis that the  struggle to survive will naturally select the strong or fittest over the weak or ill-adapted individual. But what is actually observed is that natural selection leads to stabilization of an existing species, not to a higher order - it counteracts transformation.